Tenosynovial Giant Cell Tumors Market Poised for Growth Driven by CSF1R Therapies

New York, USA, Jan. 19, 2026 (GLOBE NEWSWIRE) -- Tenosynovial Giant Cell Tumors Market to Show Significant Growth by 2034 as CSF1R-Targeted Therapies Drive the Next Wave | DelveInsight The tenosynovial giant cell tumors market is expected to grow due to rising awareness and improved disease diagnosis, the availability of advanced imaging modalities that aid earlier detection, the increasing uptake of targeted therapies such as CSF1R inhibitors, and the ongoing clinical development of novel agents such as SynOx Therapeutics' emactuzumab, Abbisko Therapeutics' pimicotinib, AmMax Bio’s AMB-051, and others addressing both localized and diffuse forms. DelveInsight’s Tenosynovial Giant Cell Tumors Market Insights report includes a comprehensive understanding of current treatment practices, emerging tenosynovial giant cell tumors drugs, market share of individual therapies, and current and forecasted tenosynovial giant cell tumors market size from 2020 to 2034, segmented into leading markets (the US, EU4, UK, and Japan). Tenosynovial Giant Cell Tumors Market Summary The total tenosynovial giant cell tumors treatment market size is expected to grow positively by 2034 in the leading markets. The United States accounts for the largest market size of tenosynovial giant cell tumors, in comparison to EU4 (Germany, Italy, France, and Spain), the UK, and Japan. According to DelveInsight analysis, there were more than 630,000 prevalent cases of TGCT in the 7MM in 2024, with the number projected to rise by 2034. Key tenosynovial giant cell tumors companies, including SynOx Therapeutics, Abbisko Therapeutics, AmMax Bio, and others, are actively working on innovative tenosynovial giant cell tumors drugs. Some of the key tenosynovial giant cell tumors therapies in clinical trials include Emactuzumab, Pimicotinib, AMB-05X, and others. These novel tenosynovial giant cell tumors therapies are anticipated to enter the tenosynovial giant cell tumors market in the forecast period and are expected to change the market. Discover which tenosynovial giant cell tumors medications are expected to grab the market share @ https://www.delveinsight.com/sample-request/tenosynovial-giant-cell-tumors-tsgcts-market?utm_source=globenewswire&utm_medium=pressrelease&utm_campaign=spr Sadaf Javed, Manager of Forecasting and Analytics at DelveInsight, commented: “With advancements in research and development, new diagnostic techniques and parameters are expected to significantly increase the diagnosis of TGCT in patients, effectively improving patient prognosis.” Key Factors Driving the Growth of the Tenosynovial Giant Cell Tumors Market Rising TGCT Cases: In 2024, the US reported approximately 230,000 localized TGCT cases and around 60,000 diffuse TGCT cases. These figures are projected to climb from 2025 to 2034, driven by improved access to high‑resolution imaging that uncovers smaller or asymptomatic lesions, heightened clinical awareness leading to earlier diagnosis and referral, demographic aging that increases overall susceptibility, and the expansion of comprehensive registry initiatives that capture a greater proportion of long‑term survivors. Advancements in Targeted Therapies: Innovation in targeted molecular therapies (e.g., kinase inhibitors like vimseltinib and CSF-1R inhibitors) and the development of novel agents are expanding the therapeutic landscape beyond traditional surgical approaches. These innovations often offer better efficacy and tolerability. Improved Diagnostic Techniques & Awareness: Advances in imaging (e.g., MRI, molecular diagnostics) and heightened awareness among clinicians and patients are driving earlier detection and improved management of TGCT, thereby supporting market growth. Emerging CSF1R-Targeted Therapies for TGCT: Several therapies are in development for TGCT, including SynOx Therapeutics' emactuzumab, Abbisko Therapeutics' pimicotinib, and AmMax Bio’s AMB-051, among others. These agents target the CSF1/CSF1R (colony-stimulating factor 1 receptor) pathway and aim to provide improved efficacy and tolerability, addressing the need for non-surgical treatment options, especially in diffuse or recurrent disease. Tenosynovial Giant Cell Tumors Market Analysis Surgical resection remains the primary treatment for TGCT, but diffuse TGCT (DTGCT) is difficult to remove completely and carries a high recurrence rate of approximately 50%, often with multiple relapses. Although DTGCT is rarely fatal, repeated surgical interventions can significantly impair quality of life by reducing joint function and increasing perioperative complications and secondary arthrosis. Systemic therapies targeting the CSF1/CSF1R pathway, including imatinib and nilotinib, have been explored after surgery to reduce morbidity and preserve function in nonlethal DTGCT with characteristic cytogenetic features. Recent advances in TGCT treatment include both less-selective tyrosine kinase inhibitors, such as imatinib and nilotinib, and the more-selective CSF1R inhibitor pexidartinib, which has demonstrated promising clinical outcomes. TURALIO (pexidartinib) became the first FDA-approved systemic therapy for patients with symptomatic TGCT who are not candidates for surgery, although its use is limited by the risk of hepatotoxicity. The recently approved ROMVIMZA (vimseltinib) offers a safer and effective systemic treatment alternative for TGCT. Additional therapies, including emactuzumab, pimicotinib, and AMB-051, are currently in development to target the CSF1/CSF1R pathway with improved efficacy and tolerability. These emerging agents aim to expand non-surgical treatment options, particularly for patients with diffuse or recurrent TGCT. Learn more about the tenosynovial giant cell tumors treatment options @ Tenosynovial Giant Cell Tumors Treatment Market Tenosynovial Giant Cell Tumors Competitive Landscape The emerging TGCT treatment landscape is expected to become increasingly competitive through 2036, driven by promising candidates such as SynOx Therapeutics' emactuzumab, Abbisko Therapeutics' pimicotinib, and AmMax Bio’s AMB-051, among others. SynOx Therapeutics' Emactuzumab is a potent, highly selective monoclonal antibody targeting CSF1R that inhibits signaling by CSF1 and IL-34, thereby reducing macrophage-driven inflammation and proliferation associated with TGCT. Abbisko Therapeutics' Pimicotinib (ABSK021) is an oral, highly selective CSF1R inhibitor under development for TGCT. By preventing CSF1R-mediated macrophage accumulation, it aims to slow disease progression in patients ineligible for surgery. AmMax Bio’s AMB-051 (AMB-05X) is a monoclonal antibody that modulates macrophage-driven inflammation and fibrosis through the AMPK signaling pathway by targeting CSF1R. Intended for intra-articular administration, it aims to treat TGCT by reducing both fibrotic and inflammatory activity. The drug has completed a Phase II trial in patients with localized or diffuse TGCT. AMB-05X has received FDA Fast Track Designation (September 2022) and EMA PRIME designation (January 2023), highlighting its promise in macrophage-driven conditions such as TGCT. Aparna Thakur, Assistant Project Manager, Forecasting and Analytics at DelveInsight, commented: “TGCT has a significantly active pipeline, with many companies like Deciphera Pharmaceuticals, SynOx Therapeutics, and Abbisko Therapeutics actively working to develop therapies for TGCT. The anticipated launch of these emerging TGCT therapies are poised to transform the SLE market landscape in the coming years.” To know more about new treatment for tenosynovial giant cell tumors, visit @ Tenosynovial Giant Cell Tumors Medication Recent Developments in the Tenosynovial Giant Cell Tumors Market In December 2025, pimicotinib was approved in China as a systemic treatment for TGCT, representing its first regulatory approval worldwide, while regulatory filings for the therapy were also underway globally based on positive data from the Phase III MANEUVER study. In September 2025, Deciphera reported that the European Commission granted marketing authorization for ROMVIMZA for the treatment of TGCT, making it the first and only therapy approved for TGCT in the European Union. In August 2025, SynOx Therapeutics completed patient enrollment in the TANGENT study, a registrational Phase III trial evaluating emactuzumab in TGCT patients who are either ineligible for surgery or unlikely to benefit from it. Top-line results from the study are anticipated in the first quarter of 2026. In April 2025, the US FDA granted Fast Track Designation (FTD) to emactuzumab for TGCT. In March 2025, Abbisko Therapeutics reported that Merck exercised its global commercialization option for pimicotinib (ABSK021), paying an option exercise fee of USD 85.0 million under the licensing agreement originally signed in December 2023. What are Tenosynovial Giant Cell Tumors? Tenosynovial giant cell tumors (TGCTs) are rare, typically benign tumors that arise from the synovium, which is the thin layer of tissue lining the joints, tendon sheaths, and bursae. They are characterized by abnormal cell growth in these tissues, often leading to joint swelling, pain, stiffness, and reduced mobility. TGCTs can be classified into two main types: localized, which usually affects a single joint and is less aggressive, and diffuse, which involves larger areas of the synovium and may be more assertive, causing joint damage over time. While benign, these tumors can recur after treatment, which often includes surgical removal, and in some cases, newer targeted therapies are being explored to manage diffuse or recurrent cases. Tenosynovial Giant Cell Tumors Epidemiology Segmentation The tenosynovial giant cell tumors epidemiology section provides insights into the historical and current tenosynovial giant cell tumors patient pool and forecasted trends for the leading markets. In 2024, localized TGCT represented the predominant growth pattern across the 7MM, with Japan reporting around 79% of its prevalent TGCT cases as localized. The tenosynovial giant cell tumors market report proffers epidemiological analysis for the study period 2020–2034 in the leading markets segmented into: Prevalent Cases of TGCT Growth Pattern-specific Prevalent Cases of TGCT Gender-specific Prevalent Cases of Localized TGCT Gender-specific Prevalent Cases of Diffuse TGCT Tumor Location-specific Prevalent Cases of Localized TGCT Tumor Location-specific Prevalent Cases of Diffuse TGCT Total Treated Cases of TGCT Download the report to understand tenosynovial giant cell tumors management @ Tenosynovial Giant Cell Tumors Treatment Options Tenosynovial Giant Cell Tumors Market Report MetricsDetailsStudy Period2020–2034Tenosynovial Giant Cell Tumors Market Report Coverage7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan]Tenosynovial Giant Cell Tumors Epidemiology SegmentationPrevalent Cases of TGCT, Growth Pattern-specific Prevalent Cases of TGCT, Gender-specific Prevalent Cases of Localized TGCT, Gender-specific Prevalent Cases of Diffuse TGCT, Tumor Location-specific Prevalent Cases of Localized TGCT, Tumor Location-specific Prevalent Cases of Diffuse TGCT, and Total Treated Cases of TGCT Key Tenosynovial Giant Cell Tumors CompaniesSynOx Therapeutics, Abbisko Therapeutics, AmMax Bio, Daiichi Sankyo, Deciphera Pharmaceuticals (now a wholly owned subsidiary of Ono Pharmaceutical), and othersKey Tenosynovial Giant Cell Tumors TherapiesEmactuzumab, Pimicotinib, AMB-05X, TURALIO, ROMVIMZA, and others Scope of the Tenosynovial Giant Cell Tumors Market Report Tenosynovial Giant Cell Tumors Therapeutic Assessment: Tenosynovial Giant Cell Tumors current marketed and emerging therapies Tenosynovial Giant Cell Tumors Market Dynamics: Conjoint Analysis of Emerging Tenosynovial Giant Cell Tumors Drugs Competitive Intelligence Analysis: SWOT analysis and Market entry strategies Tenosynovial Giant Cell Tumors Market Unmet Needs, KOL’s views, Analyst’s views, Tenosynovial Giant Cell Tumors Market Access and Reimbursement Discover more about tenosynovial giant cell tumors drugs in development @ Tenosynovial Giant Cell Tumors Clinical Trials Table of Contents 1Tenosynovial Giant Cell Tumors Market Key Insights2Tenosynovial Giant Cell Tumors Market Report Introduction3Tenosynovial Giant Cell Tumors Market Overview at a Glance3.1Tenosynovial Giant Cell Tumors Market Share (%) Distribution by Therapies by 20253.2Tenosynovial Giant Cell Tumors Market Share (%) Distribution by Therapies by 20364Executive Summary5Key events6Epidemiology and Market Methodology7Disease Background and Overview7.1Introduction of TGCT7.2Etiology of TGCT7.3Molecular biology of TGCT7.4Classification of TGCT7.5Clinical features7.6Subdivisions of TGCT on the basis of Cellular Division7.7Pathogenesis7.8Biomarkers7.9Diagnosis7.10Tenosynovial Giant Cell Tumors Treatment8Epidemiology and Patient Population8.1Key Findings8.2Assumptions and Rationale: The 7MM8.3Prevalent Cases of TGCT in the 7MM8.4The US8.4.1Prevalent Cases of TGCT in the US8.4.2Growth Pattern-specific Prevalent Cases of TGCT in the US8.4.3Gender-specific Prevalent Cases of Localized TGCT in the US8.4.4Gender-specific Prevalent Cases of Diffuse TGCT in the US8.4.5Tumor Localization of Localized TGCT in the US8.4.6Tumor Localization of Diffuse TGCT in the US8.4.7Total Treated Cases of TGCT in the US8.5EU4 and the UK8.6Japan9Tenosynovial Giant Cell Tumors Patient Journey10Marketed Tenosynovial Giant Cell Tumors Therapies10.1Key Cross Competition10.2TURALIO (pexidartinib): Daiichi Sankyo10.2.1Product Description10.2.2Regulatory Milestone10.2.3Other Developmental Activities10.2.4Summary of Pivotal Trials10.2.5Clinical Development10.2.5.1Clinical Trials Information10.2.6Safety and Efficacy10.2.7Analyst Views10.3ROMVIMZA (vimseltinib): Ono PharmaceuticalList to be continued in the report….11Emerging Tenosynovial Giant Cell Tumors Therapies11.1Key Cross Competition11.2Emactuzumab: SynOx Therapeutics11.2.1Product Description11.2.2Other Developmental Activities11.2.3Clinical Development11.2.4Clinical Trials Information11.2.5Safety and Efficacy11.2.6Analyst Views11.3Pimicotinib: Abbisko Therapeutics/Merck11.4AMB-051: AmMax BioList to be continued…12TGCT Market: The 7MM Analysis12.1Key Findings12.2Tenosynovial Giant Cell Tumors Market Outlook12.3Attribute Analysis12.4Key Tenosynovial Giant Cell Tumors Market Forecast Assumptions12.5The 7MM Tenosynovial Giant Cell Tumors Market Size12.5.1Total Market Size of TGCT in the 7MM12.5.2Market Size of TGCT by Therapies in the 7MM12.6The US Tenosynovial Giant Cell Tumors Market Size12.6.1Total Market Size of TGCT in the US12.6.2Market Size of TGCT by Therapies in the US12.7EU4 and the UK Tenosynovial Giant Cell Tumors Market Size12.8Japan Tenosynovial Giant Cell Tumors Market Size13Tenosynovial Giant Cell Tumors Market Access and Reimbursement13.1The United States13.2EU4 and the UK13.3Japan13.4Reimbursement Scenario in TGCT14KOL Views on TGCT15TGCT Market SWOT Analysis16TGCT Market Unmet Needs17Bibliography18Acronyms and Abbreviations19TGCT Market Report Methodology Related Reports Tenosynovial Giant Cell Tumors Epidemiology Tenosynovial Giant Cell Tumors Epidemiology Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted TGCT epidemiology in the 7MM, i.e., the United States, EU4 (Germany, Spain, Italy, and France), the United Kingdom, and Japan. Tenosynovial Giant Cell Tumors Clinical Trial Analysis Tenosynovial Giant Cell Tumors Pipeline Insight – 2025 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key TGCT companies, including AmMax Bio, Inc., Deciphera Pharmaceuticals, SynOx Therapeutics, Abbisko Therapeutics Co, Ltd., Hutchison Medipharma Limited, Elixiron Immunotherapeutics, among others. Rheumatoid Arthritis Market Rheumatoid Arthritis Market Insights, Epidemiology, and Market Forecast – 2034 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key rheumatoid arthritis companies, including Taisho Pharmaceuticals, R-Pharm, GlaxoSmithKline, Aclaris Therapeutics, Pfizer, Abivax, Bristol Myers Squibb, Oscotec, Genosco, Mesoblast, Pfizer Akros Pharma, Japan Tobacco, Abbvie, Horizon Therapeutics, Eli Lilly and Company, Taiho Pharmaceutical, Gilead Sciences, Kiniksa Pharmaceuticals, Istesso, SynAct Pharma, Cyxone, among others. Rheumatoid Arthritis Clinical Trial Analysis Rheumatoid Arthritis Pipeline Insight – 2025 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key rheumatoid arthritis companies, including Taisho Pharmaceutical, Zhejiang Hisun Pharmaceutical, SinoMab, Jiangsu Hengrui Medicine, RemeGen, GlaxoSmithKline, Modern Biosciences, Jiangsu Alphamab Biopharmaceuticals, Akros Pharma, Hanlim Pharm, Galapagos NV, Chong Kun Dang Pharmaceutical, Bristol Myers Squibb, AstraZeneca, Aclaris Therapeutics, Abivax, AbbVie, Synact Pharma, Gilead sciences, Mesoblast, Rottapharm Biotech, Eli Lilly and Company, Kiniksa Pharmaceuticals, Abcentra, Cyxone, Yungjin Pharm. Co., Ltd. Taiho Pharmaceutical, Oscotec Inc., Pfizer, Janssen Research & Development, Cipher Pharmaceuticals Inc., KLUS Pharma Inc., Revolo Biotherapeutics, Lynk Pharmaceuticals, Beijing Baylx Biotech, Hope Biosciences, Kangstem Biotech, Celltex Therapeutics, I-Mab Biopharma Co. Ltd., Synermore Biologics Co., Ltd, Oryn Therapeutics, Arthrogen, Bayer, Amgen, Draconis Pharma, Biozeus, Landos Biopharma, Imcyse, Kymera Therapeutics, RedHill Biopharma, 4D Pharma, CV6 Therapeutics, VYNE Therapeutics, MyMD Pharmaceuticals, Brickell Biotech Inc, Worg Pharmaceuticals, Almirall, Standigm, Metrion Biosciences, Jnana Therapeutics, Silo Pharma, SFA Therapeutics, Neutrolis Therapeutics, Ahead Therapeutics, Fresenius Kabi, Kidswell Bio, BioXpress Therapeutics, CinnaGen, Alvotech, Hetero Biopharma, Shanghai Henlius Biotech, Cadila Pharmaceuticals, Innovent Biologics, Torrent Pharmaceuticals, Emcure Pharmaceuticals, mAbxience, Shanghai Junshi Biosciences, Enosi Therapeutics, among others. 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