LbuCas13a Collateral RNA Cleavage: Unveiling Temporal Patterns in Human Cells

Researchers have investigated the temporal dynamics of collateral RNA cleavage by LbuCas13a in human cells, revealing new insights into its activity and behavior. The study focused on understanding how LbuCas13a, a CRISPR-associated RNA-guided enzyme, interacts with target and non-target RNAs over time within human cellular environments. The findings indicate that LbuCas13a exhibits specific patterns of collateral RNA cleavage after activation by a target RNA. Researchers observed that the enzyme’s activity is influenced by various factors, including the concentration of target RNA and the duration of exposure. The study also highlighted differences in cleavage efficiency across different types of non-target RNAs, suggesting variability in how LbuCas13a processes unintended substrates. These results provide a detailed view of the enzyme’s temporal behavior and may contribute to future applications or modifications in gene-editing technologies. Newsflash | Powered by GeneOnline AI Source: GO-AI-ne1 For any suggestion and feedback, please contact us. Date: January 19, 2026