Integrin α5: The Key Driver of Retinal Vascular Leakage in Diabetic Retinopathy

ANGPTL3-Integrin α5 Interaction Identified as Key Driver of Retinal Vascular Leakage in Diabetic Retinopathy Researchers have identified the ANGPTL3-integrin α5 axis as a significant factor contributing to retinal vascular leakage in diabetic retinopathy (DR), according to findings from a recent study. Diabetic retinopathy, a common complication of diabetes, is one of the leading causes of vision impairment and blindness worldwide. The study highlights how this molecular interaction plays a central role in the progression of vascular leakage, which is a hallmark feature of the disease. The research team, led by Dr. Jing Ke, investigated the mechanisms underlying retinal vascular dysfunction in DR. Their work focused on the ANGPTL3 protein and its interaction with integrin α5, revealing that alterations in this pathway exacerbate blood vessel leakage within the retina. This discovery provides new insights into how diabetic retinopathy develops at a molecular level and may inform future studies aimed at addressing this condition. The findings emphasize the importance of understanding specific biological pathways involved in DR to better address its impact on patients globally. Newsflash | Powered by GeneOnline AI Source: GO-AI-ne1 For any suggestion and feedback, please contact us. Date: January 19, 2026