FGF12 Disrupts Mechanosignaling in Aortic Cells: New Marfan Syndrome Findings

A recent study published in *Experimental and Molecular Medicine* has identified Fibroblast Growth Factor 12 (FGF12) as a key factor influencing mechanosignaling pathways in aortic smooth muscle cells. Researchers examined its role in thoracic aortic aneurysm formation, particularly within the context of Marfan syndrome, a genetic disorder affecting connective tissue. The findings provide new insights into how FGF12 disrupts cellular signaling mechanisms that are critical for maintaining vascular integrity. The study focused on mice models with Marfan syndrome to investigate the impact of FGF12 on mechanosignaling processes. Researchers observed that FGF12 interferes with normal signaling functions in aortic smooth muscle cells, which are essential for responding to mechanical stress and maintaining structural stability of the aorta. This disruption is linked to the development of thoracic aortic aneurysms, a life-threatening condition characterized by abnormal dilation of the artery wall. The research highlights FGF12’s involvement in altering cellular responses and its potential contribution to disease progression in Marfan syndrome cases. Newsflash | Powered by GeneOnline AI Source: GO-AI-ne1 For any suggestion and feedback, please contact us. Date: January 18, 2026