Revolutionary CT Contrast Agent for Enhanced Bowel Imaging

ROCHESTER, Minn. — In a new pilot feasibility study , researchers from Mayo Clinic , the University of Washington School of Medicine, the University of California San Francisco, and Nextrast Inc. found that a new imaging oral agent, also known as a "contrast agent," helps radiologists better see bowel structures and disease in CT imaging when compared with the current oral contrast agents. The introduction of a new oral contrast agent for CT imaging addresses common challenges in the diagnosis of bowel diseases, says by Joel Fletcher, M.D. , lead author on the study and medical director of the Mayo Clinic CT Clinical Innovation Center . "The new oral contrast agent," he explains, "is ingested by patients prior to CT imaging and helps detect pathologies within and outside of the bowel wall in ways current imaging agents do not." "We carefully designed this new class of oral contrast agent to overcome many of the diagnostic shortcomings of existing contrast agents for a broad range of diseases," says Benjamin Yeh, M.D. , a co-author on the study, radiologist at the University of California at San Francisco and co-founder of Nextrast, which created the new agent. "The Clinical Phase 2 results confirm that our dark agent can reveal previously impossible-to-detect findings, including very small bowel tumors and subtle inflammatory conditions that are often missed with conventional agents at CT." In their paper , the authors report findings that suggest this new agent significantly improves visualization of inflammatory bowel disease (IBD) or cancer within the abdomen, and may provide earlier and more confident diagnoses. The study compared CT scans of 32 patients with the dark borosilicate oral contrast agent and scans with conventional water or iodine-based oral contrast agents, to look at anatomical structures and disease presence. "The novel dark borosilicate contrast agent has the potential to improve the assessment of numerous pathologies, including the detection of cancer and inflammatory disorders," says Achille Mileto, M.D. , a radiologist at the University of Washington School of Medicine and first author of the study. Evaluators identified clinically relevant findings in seven patients that were not detected using the standard contrast. "CT scans performed with the new agent will likely do a better job of displaying pathologies in the stomach and proximal small bowel, areas where CT with traditional oral contrast performs poorly," Dr. Fletcher says. "Pathologies within the lumen will be better displayed because the lumen is more distended, and the brightness of the pathologies on the CT images will be increased, making them more conspicuous." The researchers say further study using a larger patient population is needed, but the initial findings show promise. Review the study for a complete list of authors, disclosures and funding.