New Study Uncovers Basal-like Traits in ER-Positive Breast Cancer

Study Identifies Basal-like Characteristics in ER-Positive HER2-Negative Breast Cancer Subtype A recent study has provided new insights into the molecular characteristics of breast cancer, specifically examining the Basal-like intrinsic molecular subtype within estrogen receptor-positive (ER-positive) cases. Researchers have identified that this subtype, typically associated with more aggressive forms of breast cancer, is also present in primary ER-positive and human epidermal growth factor receptor 2-negative (HER2-negative) tumors. The findings contribute to a growing body of evidence highlighting the complexity and heterogeneity of breast cancer subtypes. The study, conducted by Hohmann et al., focused on analyzing the Basal-like features within ER-positive breast cancers, which are traditionally considered less aggressive than their triple-negative counterparts. By employing advanced molecular profiling techniques, researchers uncovered distinct genetic and biological markers indicative of Basal-like characteristics in these tumors. These findings suggest that even within ER-positive classifications, there exists significant variability that could influence treatment responses and outcomes. The research underscores the importance of further investigating these subtypes to better understand their clinical implications. Newsflash | Powered by GeneOnline AI Source: GO-AI-ne1 For any suggestion and feedback, please contact us. Date: January 19, 2026