Health & Fitness
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New Study: Sphingolipid-Steroid Ratio Predicts Asthma Exacerbations
geneonline.com
January 19, 2026•3 days ago

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A study identified the sphingolipid-steroid ratio in blood as a potential biomarker to predict asthma exacerbations. Fluctuations in this ratio correlated with impending flare-ups. Researchers suggest monitoring this ratio could help clinicians identify high-risk patients for earlier intervention, potentially improving asthma management. Further validation is required for clinical application.
Study Identifies Sphingolipid-Steroid Ratio as Potential Predictor of Asthma Exacerbations
A recent study has identified a potential biomarker that may predict asthma exacerbations, offering new insights into managing this chronic respiratory condition. Researchers found that the ratio of sphingolipids to steroids in the blood could serve as an indicator for impending asthma flare-ups. Asthma affects millions worldwide and poses risks of severe episodes that can significantly impact quality of life or lead to fatal outcomes. Despite advancements in understanding the disease, predicting these exacerbations remains a challenge for healthcare providers.
The study analyzed blood samples from individuals with asthma and observed that fluctuations in the sphingolipid-steroid ratio correlated with periods leading up to exacerbations. Sphingolipids are lipid molecules involved in cellular signaling and inflammation, while steroids are commonly used as anti-inflammatory treatments for asthma. The researchers suggest that monitoring this ratio could help clinicians identify patients at higher risk of flare-ups, potentially enabling earlier interventions. Further research is needed to validate these findings and explore their application in clinical settings.
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Date: January 19, 2026
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