DNA Nanodevices Uncover Acidic Nanolayer on Lysosomal Surface

Researchers have identified an acidic nanolayer on the surface of lysosomes using DNA nanodevices, according to a recent study published in *Nature Cell Biology*. The findings reveal that this previously undetected feature plays a role in the lysosomal environment, which is critical for cellular processes such as waste degradation and recycling. The study utilized advanced DNA-based tools to measure pH levels at the nanoscale, providing new insights into the biochemical properties of lysosomes. The team employed DNA nanodevices capable of detecting minute changes in acidity to map the pH distribution across lysosomal surfaces. Their analysis uncovered a thin acidic layer surrounding these organelles, which had not been observed before. This discovery adds to the understanding of how lysosomes maintain their functionality and interact with other cellular components. Researchers suggest that this acidic nanolayer may influence molecular interactions at the lysosomal boundary, though further studies are needed to explore its specific roles. Newsflash | Powered by GeneOnline AI Source: GO-AI-ne1 For any suggestion and feedback, please contact us. Date: January 21, 2026